Let's limit this to the U.S. for starters (excluding Las Vegas and Atlantic City). Later we can do international. I will list some obvious low hanging fruit, then y'all add some more. Let's make sure it is (1) actually historic, and not just where you lost your virginity or whatever; and (2) make sure it is a hotel, not a spa, hospital, dude ranch, air B&B, apartment complex, theatre, duplex or rental unit, etc. If you want to, say why it is historic and your favorite. Obviously, my list is a bit Texas centric. Note this list is not the nicest or most luxurious hotels. The Four Seasons or whoever may be a better hotel than those on this list. If it has Omni or Hilton or Mariott in the name, I downgraded it a lot. Instead, this list is historic. I know some Las Vegas hotels like the Bellagio may by now be deemed historic, but those are historic gambling dens, not solely historic for being hotels. I know there are some mansions and historic houses and castles that you can rent rooms in, but I am going for real hotels here. Also, these are just the ones I am personally familiar with. I am sure there are hundreds that could be added. Just a chance for you to name your favorite historic.
Drake Hotel in Chicago, Illinois (newlyweds Marilyn Monroe and Joe DiMaggio would carve their iconic initials into the bar’s world famous wooden counter)
Driskell Hotel in Austin, TX (haunted)
Hotel Del Coronado in San Diego, CA (filmed Some Like It Hot with Tony Curtis, Marilyn Monroe, and Jack Lemmon)
Hotel Galvez in Galveston, TX
Menger Hotel in San Antonio, TX
Waldorf-Astoria, NY (Bartenders at the Waldorf Astoria in New York City created the Rob Roy to celebrate the opening of Rob Roy the operetta. )
Stagecoach Inn, Salado, TX (Sam Houston, George Custer, and Jesse James stayed there)
the Hermitage Hotel, Nashville, TN
the Gage Hotel, Marathon, TX
Hotel Settles, Big Spring, TX
Hotel Texas, Fort Worth, TX (Jim Thompson worked as a bellboy at the Hotel Texas for two years during Prohibition)
the Adolphus Hotel, Dallas, TX
the Whitehall, Houston TX
the Marlin Hotel, Miami, FL
the Beverley Hills Hotel, Hollywood, CA
the Roosevelt Hotel, Los Angeles, CA
Chateau Marmont, Los Angeles, CA
Hotel Bel-Air, Los Angeles, CA
Beverley Wilshire, Los Angeles, CA
Millennium Biltmore, Los Angeles, CA
Palace Hotel, SF, CA
Ritz-Carlton, SF, CA
the St. Francis SF, CA
Hay-Adams, Washington, DC
Hamilton Hotel, Washington DC
the Mayflower Inn, Washington DC
Hotel Lombardy, Washington DC
Fairmont Olympic, Seattle WA
Lord Baltimore Hotel, Baltimore, Maryland
Old Santa Fe Inn, Santa Fe, NM
the Broadmoor, Colorado Springs CO
the Pfister Hotel, Milwaukee, Wisconsin
the Dewberry, Charleston SC
Francis Marion Hotel, Charleston SC
1886 Crescent Hotel, Eureka Springs, Ark
the Grand Hotel. Mackinac Island Michigan
Lake Yellowstone Hotel, Yellowstone Park, Wyoming
the Wort Hotel, Jackson, Wyoming
Brown Palace, Denver CO
General Morgan Inn, Greenville TN (The Thunderbolt of the Confederacy)
Capital Hotel, Little Rock, Arkansas
Hotel Bethlehem, Bethlehem, PA
the Edgewater, Madison, Wisconsin
Dunhill Hotel, Charlotte NC
Brown Hotel, Louisville Kentucky
Balfour Hotel, Miami, FL
The Plaza, NY, NY
Stanley Hotel. Estes Park, CO
French Lick Springs Hotel, French Lick, IN
Fountainebleau, Miami, FL
Hotel Chelsea, NY, NY
Algonquin Hotel, NY, NY
St Regis, NY, NY (The Bloody Mary invented here)
Carlyle, Madison Ave, NY, NY (site of JFK and Marilyn Monroe affairs)
Knickerbocker, NY, NY (claim is the Martini was invented here at John D. Rockefeller's request)
Lotte NY Palace, NY, NY
Liberty Hotel, Boston, Mass
Detroit Foundation Hotel, Detroit, Michigan
Biltmore, Coral Gables, FL
The Breakers, Palm beach, FL
Florida House Inn, FL
Gasparilla Inn, Boca Grande FL
Colony Hotel, Delrey Beach, FL
Jefferson Hotel, Richmond VA
Blackburn Inn, Staunton VA
Netherland Plaza, Cincinnati, OH
Golden Lamb Hotel, Lebanon, OH
Great Southern Hotel, Columbus, OH
the Arcade, Cleveland OH
Tudor Arms, Cleveland OH
P.S. I know the Watergate is famous, but not famous for being a hotel, nor is its historical significance because it is a hotel. Yes, various Trump Hotels are newly famous, but not long-time famous, nor historic.