Senescent Cells and Aging
Cellular Senescence - Is a process by which cells stop replicating after a set amount of time – This is vital to prevent devastating cancers but also contributes to age-related diseases. Every time a cell replicates, its DNA accumulates and a number of errors may occur. If cells replicate unchecked, these errors can snowball, forming masses of non-functioning cells that lead to malignant cancers. Senescent cells, which are alive but no longer dividing, can build up in a person’s tissues, release harmful toxins, and contribute to age-related health issues. It is estimated that 7% of all our living cells are senescent at the time of death.
Studies - Reducing the number of senescent cells in people’s bodies could extend human lives. Studies in mice have shown that removing senescent cells can help mice live longer and maintain their physical abilities. Treated mice lived, on average, 36 percent longer than mice that retained senescent cells. Furthermore, old mice that were given a drug that reduces the number of senescent cells were able to survive COVID-19 in significantly higher numbers than old mice not given the drug. Several human trials are testing drugs that reduce populations of senescent cells targeting specific diseases, such as age-related macular degeneration, glaucoma, and chronic obstructive pulmonary disease. We are already seeing positive results from the early studies, and presently, when using the most common combination, Dasatinib and Quercetin (referred to as D&Q), the studies show little to no side effects.
The literature is flooded with examples of how removal of senescent cells not only extends lifespan, but thwarts the diseases of aging as well. Currently, one company is completing a phase 3 trial providing D&Q combination to treat age-related macular degeneration. Interim data is positive, and the combination seems well-tolerated. The same company is in phase 2 trials targeting Alzheimer’s and type 2 diabetes.
At OB Men, we are the first in Houston to offer this cutting-edge anti-aging therapy. We utilize Tailor Made compounding pharmacy, whic is the first FDA oversight Texas compounding pharmacy to offer the D&Q combination, which is taken once every 6 months at a cost of only $350. If you are open to cutting-edge anti-aging therapies, look to OB Men.
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Checking in "Behind Enemy Lines"
Before jumping into the weeds on our local enemies, I want to remind everyone about all of the events going down today (Tuesday, March 25th) on the 40 acres.
- 9 am (Texas Football Spring Practice)
- 11 am (Texas Basketball New Coach Sean Miller Press Conference)
- 1 pm (Texas Football NFL Pro Day) on SEC Network
- 2 pm (Texas Women Basketball Potential Commitment from #1 Player in America Aaliyah Chavez from Lubbock, TX) on ESPN
- 6 pm (4. Texas Softball hosting Stephen F. Austin at McCombs Field) on SEC Network+
- 6:30 pm (7. Texas Baseball hosting Sam Houston State at the Disch) on SEC Network+
Texas Longhorns (5 Things I want to hear from Spring OTAs)
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