The Latest in Regenerative Medicine
Exosomes
As a physician, I’m increasingly intrigued by exosome therapy—a cutting-edge tool in regenerative medicine and anti-aging. Exosomes are extracellular vesicles, nanoscale packages, delivered intravenously to leverage the body’s innate repair mechanisms. For patients exploring regenerative options, this offers a compelling alternative to traditional interventions like direct stem-cell therapies. Unlike more invasive procedures, exosomes provide systemic delivery, potentially addressing issues ranging from joint degeneration and neurological decline to anti-aging benefits, including improved skin.
The mechanism is fascinating: exosomes, typically sourced from mesenchymal stem cells (MSCs), act as biological couriers. They circulate through the bloodstream, homing in on inflammation or tissue damage. Loaded with bioactive cargo—growth factors, cytokines, and microRNAs—they interact with target cells to modulate inflammation, promote tissue regeneration, and enhance cellular function. This precision delivery sidesteps many challenges of direct stem cell therapy, offering a streamlined, cell-free approach that’s both practical and promising for clinical application.
The benefits are where this therapy shines. Patients may experience reduced inflammation, a key driver in chronic conditions like osteoarthritis or autoimmune disorders, alongside accelerated tissue repair—think tendon injuries or post-surgical recovery. Emerging evidence also suggests potential neuroprotective effects, with exosomes crossing the blood-brain barrier to support neuronal health. This could prove transformative for conditions like traumatic brain injury or early neurodegeneration. The reported energy and overall wellness improvements are equally noteworthy for my patients seeking non-pharmacological ways to reclaim vitality. Also, the overall benefits for a more youthful appearance are impressive.
What sets exosomes apart, particularly from stem cell therapies, is their safety and accessibility. Being acellular, they minimize risks like immune rejection or tumorigenesis, while their small size enhances biodistribution, reaching sites like the central nervous system that stem cells often can’t. Moreover, the cost is four to six times less than typical stem-cell therapies.
At OB Men. We emphasize the importance of sourcing high-quality exosomes from well-characterized MSC lines and administering them under strict protocols. If you are open to cutting edge anti-aging therapies, look to OB Men.
To dive deeper: Yin K, Wang S, Zhao RC. Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm. Biomark Res. 2019;7:8. Published 2019 Apr 4. doi: 10.1186/s40364-019-0159-x
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Checking in "Behind Enemy Lines"
Reminder: The point of Behind Enemy Lines is to keep not only myself but all of Longhorn Nation locked into what is happening around us, prepare for the unexpected - compare and contrast what other programs are doing from a Roster Management, Recruiting, Coaching, Playing and Staffing perspective. A lot of today's note are going to "pro" the respective team, because that is the way the respective sites might write the notes. Like usual, I'll relay the information and give my thoughts at the end.
Oklahoma (207 days until)
- SPRING STAND OUTS- A source added that youthful depth is better and also the transfers (JaVonnie Gibson) stood out on Thursday.
- WR Stand Outs: "Sources told OUInsider, "The portal guys made plays. Javonnie Gibson will be the number one. He had a TD in live full portion and a few situational as well. I think he will be the playmaker for the room. Maybe even more than what is expected with Deion Burks," a source said. "He has a great rapport with Mateer and [Michael] Hawkins. He also makes 50/50 balls more of a 70/30 ball because his hands are so strong. He has won far more than he's lost all spring when it comes to jump balls."
- OL Improvements?: "The OL looked good, man. Maybe it was me comparing to last year and the QB play making it look better. Maybe they are just that much better. I am holding my breath on the latter and that it's not just some smoke and mirrors, because I really do think they are doing some good things upfront," a source told OUInsider on how things went for the OL during Thursday's scrimmage. "They weren't winning every rep. Not even close to that. That just isn't gonna happen when you go against that defensive line. But it's a battle in the trenches more than it was last year."
- Offensive Improvement: "[Ben] Arbuckle'soffense is fun to watch. They are competing more than last year. It looks like the biggest issues have been somewhat addressed," the source told OUInsider of their thoughts on the Sooners' offense after two scrimmages this spring.
- "With [John] Mateer at QB and his experience, it's just making others better. Even the young guys on the offensive line. They were forced to play last year and that experience made them better. You add [Derek] Simmons at the right tackle spot and freshmen like [Michael] Fasusi, and you have some depth and talent that might have been missing last year."
- On The Running Backs: "RB Xavier Robinson and RB Gavin Sawchuk took first-team reps. Robinson made several plays. He scored a TD in live session and in the inside run portion and situational. Sawchuk has added some good weight, per a few sources. One added, "Gavin [Sawchuk]has been more physical this spring. He's added some really good weight and that allowed him to make some good runs, even when the blocking wasn't the best. That is different than what we saw last year, and he looks more like and SEC back in size with his new weight."
- "Right now, I think X would be the guy to start if the season was to begin today." Just going off what sources have told Parker and I."
- Defensive Note: "I told you R Mason Thomas was the best player on the DL and when he got healthy he became that," a source reminded me. "Danny Okoye is next. He is gonna be really, really good when he gets it all down and he's getting closer. Just an absolute freak off the edge."
- RECRUITING - ....
- Oddly enough, there is just a TON of names that are nowhere near the Texas Longhorns Recruiting Board that is updated by @Suchomel each week. OUInside is mostly random 3-stars. There was one note about an offensive lineman and Jordan Clay however,
- "The Sooners continue to battle Texas, Texas A&M and SMU for Pupungatoa Katoa, and they're heavy in the mix for Flower Mound (Texas) product Drew Evers. (Both have been downward trends on the Recruiting Board in March)
- Jordan Clay, WR from Madison High School on his fit: “I got three things," explained Clay. "I go coaches, culture and an offense that fits me. So if you got a great culture, you got a good coaching staff that knows how to develop — not just as a football player, but as a man too — and then they got a scheme that fits me, that’s the things I look for in a school. I’m not about logos and who gives me the most money. I want to go where I’m loved.”
- Although the Sooners, Buffs and Bears are in the strongest position with Clay for the time being, he isn't done evaluating his full range of options. In the next few weeks, he intends to hit the road for several unofficials, which could in turn lead to the scheduling of some additional OV's.
- “I’m gonna be back up at Texas, and I’m going to go to A&M," Clay disclosed. "I’m gonna try to get up to Nebraska, and then Tennessee.”
Cody's Thoughts: I've read a ton about JaVonnie Gibson, the transfer Wide Receiver from Arkansas Pine-Bluff over the last few months. He was Overall #112 in the Portal, and WR26 just behind former Sooner Jalil Farooq, who left for Maryland. Gibson has 70 catches, 1,215 yards and 9 touchdowns during his Sophomore season at 6'3 205 lbs. (below is some highlight footage of Gibson). Also, this offense is likely an improvement in 2025, but I'm not going to run out to best case scenario and bet on all these freshman and sophomores + a Washington State QB and Arkansas Peanut-Butter All-Conference receiver taking this thing about .500
All notes are from OUINSIDER.com, not my own sourcing.
Texas A&M (242 days until)
- SPRING STAND OUTS- KC Concepcion, Mario Craver, Kelshaun Johnson, and Ashton Bethel-Roman at WR, Amari Niblack at TE.
- WR Stand Out: AggieYell Insider Mark Passwaters on Concepcion: “It's very early, but Concepcion looks like A&M's most complete receiver since Christian Kirk. He's fast, he runs good routes and he finds ways to get open. And, obviously, he's productive."
- On Kelshaun Johnson: "Johnson is just flat out fast. I wasn't sure he'd be built enough to handle the SEC grind as a freshman, but he looks ok to me. If he can catch the ball consistently (I'm not saying he hasn't, I'm just trying to make a point), then his speed may make it impossible to keep him off the field. He's that kind of burner."
On Niblack: "A&M really needs size amongst its pass catchers, and that's where Niblack (and Kiotti Armstrong) comes in. I know he didn't get a lot of work last year at Texas, but Gunnar Helm did not exactly suck (786 yards and 13.1 YPC). The only year Niblack got a real chance to play was 2023, and he caught 21 passes for 16.3 yards a reception and four touchdowns. He can catch, and that's what A&M needs from him. From what little we've seen, he looks like a fluid runner and a steady receiver, which would fit the bill."
- RECRUITING VISIT RECAP- Zaden Krempin, OT - Prosper, TX
- Elko and Adam Cushing both stopped by Prosper (Texas) High School in Dallas during the Contact Period to meet with Krempin and his family.
- "I got to meet and hang out with several offensive linemen and I spent a lot of one on one time with Coach Cushing, Coach Elko and Coach (Colin) Klein. We talked a lot scheme, culture, and overall how I would fit in at A&M," Krempin said.
- RECRUITING VISIT RECAP - KJ Edwards, RB - Carthage, TX
- KJ Edwards is set to come off the board on August 2 -- and will choose from a few in-state heavyweights.
- "Everything was good just seeing the guys going to work and grinding and just the overall genuine vibes the staff showed to me and my family every time we step foot in Aggieland," Edwards said. "Every time we're there, we know we’re going to enjoy our day every single time."
- RECRUITING VISIT RECAP - Bryce Perry-Wright, DE - Buford, GA
- "It was a great weekend at A&M," Perry-Wright said. "They show me a lot of love and showed me what it means to become an Aggie. The environment was awesome. They just wanna to win and have fun doing it. Just to get the knowledge from Coach Elko, Coach Tony (Jerod-Eddie), and Coach (Sean) Spencer was a great."
- “They taught me how to come in to work and be the best you can be — and they taught me things I can work on,” he offered. “I definitely will back.”
QB: Marcel Reed/Jacob Zeno
RB: Le'Veon Moss/Rueben Owens
TE: Theo Ohrstrom/ Nate Boerkircher
TE: Amari Niblack/Kiotti Armstrong
WR: KC Concepcion/Jerome Myles
WR: Mario Craver/Kelshaun Johnson
WR: Terry Bussey OR Ashton Bethel-Roman
LT: Trey Zuhn/Robert Bourdon OR Lamont Rogers
LG: Chase Bisontis/Blake Ivy
C: Mark Nabou OR Koli Faaiu
RG: Ar'maj Reed-Adams/Papa Ahfua
RT: Dametrious Crownover/Deuce Fatheree
DE: TJ Searcy OR Deyon Hayes
DT: Albert Regis/Tyler Onyedim
DT: DJ Hicks/Dealyn Evans
DE: Cashius Howell/Solomon Williams
JACK: Rylan Kennedy/Marco Jones
LB: Taruean York/Jordan Lockhart
LB: Scooby Williams/Daymion Sanford
NICKEL: Tyreek Chappell/Jordan Shaw
CB: Will Lee/Adonyss Currie
S: Bryce Anderson/Marcus Ratcliffe
S: Dalton Brooks/Myles Jones
CB: Julian Humphrey OR Dezz Ricks
Cody's Thoughts: I find the Amari Niblack update interesting, almost as if Niblack was "not allowed" to play because of Helm in 2024. He's currently working alongside a true freshman in Kiotti Armstrong (who is good), but that should tell you all you need about Niblack. The dynamic of the A&M offense will be interesting, with all of the outside pieces they added this winter and the positive notes puring out, it would infer a pass heavy offense, but with the strength of the OL, RB, QB being running the ball.. it's a bit of a contradiction. Looks like Zaden Krempin, KJ Edwards and Bryce Perry-Wright will be a few big wars between the Burnt Orange and Aggies, all three are 40%+ leans from @Suchomel right now for Texas.
All notes are from AGGIEYELL.com, not my own sourcing.
Georgia (228 days until)
- SPRING NOTES- Gunner Stockton at QB?
- Kirby Smart has remarked multiple times about how youthful this Georgia team is. Yet Stockton, who has made just one start in his Georgia career, is going through his fourth spring practice in Athens.
- "I mean, he understands what we're trying to do," Smart said. "He's been through it. I mean, I think about if we had all Gunners at every position. They understand the volume of reps, what we're trying to do. He knows the offense inside and out. Then I get frustrated and impatient when other guys don't know it like him and you have to kind of slow yourself down."
- Smart said Stockton "continues to grow and get better" during this pivotal spring. Both he and redshirt freshman Ryan Puglisi are working hard as the quarterback battle continues.
- G-Day (Georgia Spring Game) will kick off at 1pm on April 12th.
- The Defensive Line: "Georgia's defensive line will look much different in 2025." Jed May from UGASports wrote, losing 4 players to the NFL, "Jordan Hall is one of those who will be counted on to replace that quartet. But in a press conference this week, Hallpointed out a pair of teammates who shouldn't be forgotten."
- The first is redshirt freshman Joseph Jonah-Ajonye. The former top-100 prospect played in four games in 2024, including the first 3, before missing the final two months due to a lower leg injury.
- Five-star freshman Elijah Griffin has already turned heads in Athens. During an interview at Pro Day, Warren Brinson referred to him as the next Jalen Carter.
Cody's Thoughts: That is some mighty high praise for the incoming five-star, Elijah Griffin. Being a stand-out is one thing as a freshman at Georgia, but pulling a "next Jalen Carter" is another level. This team is going to be young in 2025, with injuries at the RB and WR position already (depth), I'd expect the Bulldogs to potentially poke around the Portal as well. Nate Frazier the Running Back that Texas got to see in 2024 is rumored to have taken a big step forward with the departure of Trevor Etienne in the Draft. We'll see about Gunner Stockton, I'm not yet sold.. but in College, sometimes it doesn't matter for a Georgia/Alabama.
All notes are from UGASports.com, not my own sourcing.
Checking in on the Consensus NFL Mock Draft Database Big Board/Mock Draft ADP with a (+/-) from October until Today (April 1st)
The NFL Draft is 23 Days Away, and Texas is currently projected for 13 draft picks, per Mock Draft Database. @Alex Dunlap and I both believe Hayden Conner will be drafted as well.
- 1st Round
- 15th - Kelvin Banks, OT (-11)
- 16th - Jahdae Barron, DB (+43)
- 20th - Matthew Golden, WR (+142)
- 2nd Round
- 56th - Alfred Collins, DT (+229)
- 3rd Round
- 68th - Cam Williams, OT (+21)
- 72nd - Isaiah Bond, WR (-47)
- 85th - Andrew Mukuba, S (+48)
- 91st - Quinn Ewers, QB (-79)
- 99th - Gunnar Helm, TE (+5)
- 4th Round
- 119th - Vernon Broughton, DL (+254)
- 5th Round
- 133th - Barryn Sorrell, EDGE (+128)
- 6th Round
- 162nd - Jaydon Blue, RB (+208)
- 7th Round
- 242nd - Jake Majors, C (-133)
- P-UDFA
- 325th - David Gbenda, LB
- 357th - Hayden Conner, OL
- 381st - Silas Bolden, WR
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